Title : Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis.

Pub. Date : 2017 Aug 11

PMID : 28798402






1 Functional Relationships(s)
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1 Mechanistically, proteasomal-impairment-induced ER stress, CHOP upregulation and disruption of Ca2+ homeostasis were found to be critically involved in the bortezomib/nutlin-3-induced dilation of the ER. nutlin 3 DNA damage inducible transcript 3 Homo sapiens