Pub. Date : 2019 Jun
PMID : 28795389
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracellular calcium ion was imaged to verify PA on mu-opioid receptor (MOR). | patchouli alcohol | opioid receptor, mu 1 | Mus musculus |
| 2 | Cellular experiments were carried out to find out COX2 and MOR expression induced by PA. | patchouli alcohol | opioid receptor, mu 1 | Mus musculus |
| 3 | PA also up-regulated COX2 mRNA and protein (P<0.05) with a down-regulation of MOR (P<0.05) both in in vivo and in vitro experiments, which devote to the analgesic effect of PA. | patchouli alcohol | opioid receptor, mu 1 | Mus musculus |
| 4 | PA showed the characters of enhancing the MOR expression and reducing the intracellular calcium ion similar to opioid effect. | patchouli alcohol | opioid receptor, mu 1 | Mus musculus |
| 5 | CONCLUSIONS: Both COX2 and MOR are involved in the mechanism of PA"s anti-nociceptive effect, and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA"s effect on MOR. | patchouli alcohol | opioid receptor, mu 1 | Mus musculus |
| 6 | CONCLUSIONS: Both COX2 and MOR are involved in the mechanism of PA"s anti-nociceptive effect, and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA"s effect on MOR. | patchouli alcohol | opioid receptor, mu 1 | Mus musculus |