Title : Genotyping and phenotyping of CYP2D6 and CYP3A isoenzymes in patients with alcohol use disorder: correlation with haloperidol plasma concentration.

Pub. Date : 2017 Sep 26

PMID : 28787271






1 Functional Relationships(s)
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1 CYP2D6 and CYP3A were phenotyped with HPLC-MS using the concentration of endogenous substrate of the enzyme and its urinary metabolites [6-hydroxy-1,2,3,4-tetrahydro-beta-carboline(6-HO-THBC) to pinoline ratio for CYP2D6 and 6-beta-hydroxycortisol to cortisol ratio for CYP3A]. 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline cytochrome P450 family 3 subfamily A member 4 Homo sapiens