Title : Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.

Pub. Date : 2017 Aug

PMID : 28765120






4 Functional Relationships(s)
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1 In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), which, upon autocrine signaling through the EP receptor, activates IDO1 via the PKC and PI3K pathways. Dinoprostone indoleamine 2,3-dioxygenase 1 Homo sapiens
2 In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), which, upon autocrine signaling through the EP receptor, activates IDO1 via the PKC and PI3K pathways. Dinoprostone indoleamine 2,3-dioxygenase 1 Homo sapiens
3 In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), which, upon autocrine signaling through the EP receptor, activates IDO1 via the PKC and PI3K pathways. Dinoprostone indoleamine 2,3-dioxygenase 1 Homo sapiens
4 In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), which, upon autocrine signaling through the EP receptor, activates IDO1 via the PKC and PI3K pathways. Dinoprostone indoleamine 2,3-dioxygenase 1 Homo sapiens