Pub. Date : 2017 Sep 15
PMID : 28760828
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To determine the functional consequence of this HDAC6-regulated phosphorylation event, we examined tau"s ability to promote microtubule assembly and found that phosphorylation of Ser-324 interferes with the normal microtubule-stabilizing function of tau. | Serine | microtubule associated protein tau | Homo sapiens |
| 2 | To determine the functional consequence of this HDAC6-regulated phosphorylation event, we examined tau"s ability to promote microtubule assembly and found that phosphorylation of Ser-324 interferes with the normal microtubule-stabilizing function of tau. | Serine | microtubule associated protein tau | Homo sapiens |
| 3 | Tau phosphorylation of Ser-324 (pSer-324) has not previously been evaluated in the context of tauopathy, and here we observed increased deposition of pSer-324-positive tau both in mouse models of tauopathy and in patients with Alzheimer"s disease. | Serine | microtubule associated protein tau | Homo sapiens |
| 4 | These findings uncover a novel acetylation-phosphorylation switch at Lys-321/Ser-324 that coordinately regulates tau polymerization and function. | Serine | microtubule associated protein tau | Homo sapiens |