Title : Is dopamine-induced inhibition of adenylate cyclase involved in the autoreceptor-mediated negative control of tyrosine hydroxylase in striatal dopaminergic terminals?

Pub. Date : 1986 Nov

PMID : 2876053






2 Functional Relationships(s)
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1 Furthermore, compared to TH extracted from control tissues, that from 7-OH-DPAT-exposed striatal slices was more sensitive to the stimulatory effects of exogenous heparin and cyclic AMP-dependent phosphorylation. Cyclic AMP tyrosine hydroxylase Rattus norvegicus
2 These data suggest that presynaptic DA autoreceptors modulate the activity of TH by controlling the degree of cyclic AMP-dependent phosphorylation of the enzyme. Cyclic AMP tyrosine hydroxylase Rattus norvegicus