Title : Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation.

Pub. Date : 2017 Sep 29

PMID : 28756264






2 Functional Relationships(s)
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1 A docking study of the most active compound 8k revealed key interactions between 8k and MMP-3 in which the sulfonamide moiety and the dipeptide group were important for improving activity. Dipeptides matrix metallopeptidase 3 Homo sapiens
2 Thus, we conclude that DHAA dipeptide derivatives containing the sulfonamide moiety may be the potential MMPs inhibitors with the ability to suppress cells migration. Dipeptides matrix metallopeptidase 3 Homo sapiens