Protein Name matrix metallopeptidase 3
Organism Homo sapiens
Gene ID 4314
Gene Symbol

MMP3

UniProt P08254 (MMP3_HUMAN)
Relationships Total Number of functionally related compound(s) : 703
Total Number of Articles : 817
Description

matrix metallopeptidase 3

Gene Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

synonyms
  • stromelysin-1
  • matrix metalloproteinase 3 (stromelysin 1, progelatinase)
  • proteoglycanase
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Properties