Title : Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats.

Pub. Date : 2017 Sep 14

PMID : 28755970






1 Functional Relationships(s)
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1 Meanwhile, the membrane permeability and efflux by P-glycoprotein (P-gp) were examined by in situ single-pass intestinal perfusion with and without P-gp inhibitor verapamil. Verapamil ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus