Title : Enantioselective Synthesis of Quaternary Δ4 - and Δ5 -Dehydroprolines Based on a Two-Step Formal [3+2] Cycloaddition of α-Aryl and α-Alkyl Isocyano(thio)acetates with Vinyl Ketones.

Pub. Date : 2017 Sep 18

PMID : 28753731






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1 A divergent synthesis of optically active quaternary Delta4 - and Delta5 -dehydro prolines is developed based on the first catalytic enantioselective conjugate addition of alpha-substituted isocyano(thio)acetates to vinyl ketones that is general for both alpha-aryl and alpha-alkyl isocyano(thio)acetates. quaternary delta like canonical Notch ligand 4 Homo sapiens