Title : LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.

Pub. Date : 2017 Sep 8

PMID : 28739799






1 Functional Relationships(s)
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Protein Name
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1 Specifically, LGR5 decreased levels of IQGAP1 phosphorylation at Ser-1441/1443, leading to increased binding of Rac1 to IQGAP1 and thus higher levels of cortical F-actin and enhanced cell-cell adhesion. Serine IQ motif containing GTPase activating protein 1 Homo sapiens