Pub. Date : 2017 Sep
PMID : 28737828
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TAZ inhibition restores sensitivity of cisplatin via AKT/mTOR signaling in lung adenocarcinoma. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | When the AKT/mTOR pathway was blocked in A549 and H460 with TAZ overexpression, cisplatin sensitivity was assessed by IC50 value. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Furthermore, we found that the inhibition of the AKT/mTOR pathway rescued the cells from cisplatin resistance caused by TAZ overexpression. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | Our data revealed that TAZ inhibition restores sensitivity of cisplatin in lung adenocarcinoma, which was, at least in part, AKT/mTOR signaling pathway-dependent. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |