Title : Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation.

Pub. Date : 2017 Jul 20

PMID : 28726774






1 Functional Relationships(s)
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1 IL-22 could also markedly reduce high glucose-induced and TGF-beta1-induced overexpression of fibronectin and collagen IV in mouse renal glomerular mesangial cells in a dose-dependent manner, suggesting the potential role of IL-22 to inhibit the overproduction of ECM in vitro. Glucose fibronectin 1 Mus musculus