Pub. Date : 2017 Jul 19
PMID : 28724388
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that inhibition of OGA by thiamet G at nanomolar concentrations significantly increased protein O-GlcNAcylation, activated MTOR, decreased autophagic flux, and increased alpha-synuclein accumulation, while sparing proteasomal activities. | thiamet G | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Inhibition of MTOR by rapamycin decreased basal levels of protein O-GlcNAcylation, decreased AKT activation and partially reversed the effect of thiamet G on alpha-synuclein monomer accumulation. | thiamet G | mechanistic target of rapamycin kinase | Homo sapiens |