Pub. Date : 2017 Oct
PMID : 28723731
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The aim of this study was to clarify the impact of the reduced function CYP2B6*6 variant allele together with variants in other candidate genes on a steady-state methadone concentration in a naturalistic setting. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The estimated mean methadone C/D ratios was 17.8 nmol L mg for homozygous carriers of CYP2B6*6, which was significantly (P < 0.001) higher than noncarriers (9.2 nmol L mg). | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | CONCLUSIONS: Patients homozygous for CYP2B6*6 had a >90% higher methadone C/D ratio. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | Genotyping of CYP2B6 may therefore be of value when assessing dose requirements in methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |