Pub. Date : 2017 Aug 16
PMID : 28723216
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression. | Lycopene | NADPH oxidase 4 | Homo sapiens |
| 2 | However, the role of NOX4 in the anti-metastatic action of lycopene remains unknown. | Lycopene | NADPH oxidase 4 | Homo sapiens |
| 3 | We showed that lycopene significantly inhibited NOX4 protein expression, with the strongest inhibition of 64.3 +- 10.2% (P < 0.05) at 2.5 muM lycopene. | Lycopene | NADPH oxidase 4 | Homo sapiens |
| 4 | Lycopene also significantly inhibited NOX4 mRNA expression, NOX activity, and intracellular ROS levels in SK-Hep-1 cells. | Lycopene | NADPH oxidase 4 | Homo sapiens |
| 5 | Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells. | Lycopene | NADPH oxidase 4 | Homo sapiens |
| 6 | Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells. | Lycopene | NADPH oxidase 4 | Homo sapiens |
| 7 | The results demonstrate that the downregulation of NOX4 plays a crucial role in the anti-metastatic action of lycopene in SK-Hep-1 cells. | Lycopene | NADPH oxidase 4 | Homo sapiens |