Protein Name NADPH oxidase 4
Organism Homo sapiens
Gene ID 50507
Gene Symbol


UniProt Q9NPH5 (NOX4_HUMAN), B7Z529 (B7Z529_HUMAN), B3KQ17 (B3KQ17_HUMAN), B7Z523 (B7Z523_HUMAN)
Relationships Total Number of functionally related compound(s) : 477
Total Number of Articles : 867

NADPH oxidase 4

Gene Summary

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

  • NADPH oxidase 4
  • kidney oxidase-1
  • kidney superoxide-producing NADPH oxidase
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