Title : Activation of the B-cell receptor successively activates NF-κB and STAT3 in chronic lymphocytic leukemia cells.

Pub. Date : 2017 Nov 15

PMID : 28722170






3 Functional Relationships(s)
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1 In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. Tyrosine interleukin 6 Homo sapiens
2 In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. Tyrosine interleukin 6 Homo sapiens
3 The IgM-induced production of IL-6 prompted the phosphorylation of STAT3 on tyrosine residues. Tyrosine interleukin 6 Homo sapiens