Pub. Date : 2017 Sep
PMID : 28720682
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase. | Formaldehyde | epidermal growth factor receptor | Homo sapiens |
| 2 | BACKGROUND: False-positive EGFR T790M mutations have been reported in formalin-fixed lung tumors, but the cause of the false positives has not been identified. | Formaldehyde | epidermal growth factor receptor | Homo sapiens |
| 3 | RESULTS: Artifactual EGFR T790M mutations were detected in all of the archival formalin-fixed normal lung and lung squamous cell carcinomas at mutant allele frequencies of 1% or lower. | Formaldehyde | epidermal growth factor receptor | Homo sapiens |
| 4 | Pretreatment of the formalin-fixed DNA with either UDG or TDG reduced the false EGFR T790M mutations, but a greater reduction was seen with the TDG treatment. | Formaldehyde | epidermal growth factor receptor | Homo sapiens |
| 5 | CONCLUSIONS: Both U:G and T:G lesions in formalin-fixed tissue are sources of false-positive EGFR T790M mutations. | Formaldehyde | epidermal growth factor receptor | Homo sapiens |