Title : Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast.

Pub. Date : 2017 Sep 15

PMID : 28720663






1 Functional Relationships(s)
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1 Earlier work demonstrated that the endolysosomal lipid PI(3,5)P2 activates V-ATPases containing the vacuolar a-subunit isoform in Saccharomyces cerevisiae Here we demonstrate that PI(4)P, the predominant Golgi phosphatidylinositol (PI) species, directly interacts with the cytosolic amino terminal (NT) domain of the yeast Golgi V-ATPase a-isoform Stv1. phosphatidyl (3,5) inositol biphosphate H(+)-transporting V0 sector ATPase subunit a Saccharomyces cerevisiae S288C