Title : FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism.

Pub. Date : 2017 Jul 17

PMID : 28717222






1 Functional Relationships(s)
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1 Mechanistic evidence suggests that FTY720-induced apoptosis was associated with its ability to inhibit Akt-NF-kappaB signaling, to facilitate the proteasomal degradation of the antiapoptotic protein Mcl-1, and to increase reactive oxygen species (ROS) generation. Fingolimod Hydrochloride MCL1 apoptosis regulator, BCL2 family member Homo sapiens