Title : Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide.

Pub. Date : 2017 Oct 1

PMID : 28705807






4 Functional Relationships(s)
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1 The inhibitory effect of l-cysteine, but not NaHS, on PDE5 activity was blocked in cells transfected with CSE siRNA or treated with CSE inhibitor d,l-propargylglycine (dl-PPG), suggesting activation of CSE and generation of H2S in response to l-cysteine. Cysteine cystathionine gamma-lyase Homo sapiens
2 The inhibitory effect of l-cysteine, but not NaHS, on PDE5 activity was blocked in cells transfected with CSE siRNA or treated with CSE inhibitor d,l-propargylglycine (dl-PPG), suggesting activation of CSE and generation of H2S in response to l-cysteine. Cysteine cystathionine gamma-lyase Homo sapiens
3 The inhibitory effect of l-cysteine, but not NaHS, on PDE5 activity was blocked in cells transfected with CSE siRNA or treated with CSE inhibitor d,l-propargylglycine (dl-PPG), suggesting activation of CSE and generation of H2S in response to l-cysteine. Cysteine cystathionine gamma-lyase Homo sapiens
4 H2S levels were increased in response to l-cysteine, and the effect of l-cysteine was augmented by GSNO in a cGMP-dependent protein kinase-sensitive manner, suggesting augmentation of CSE/H2S by cGMP/PKG pathway. Cysteine cystathionine gamma-lyase Homo sapiens