Pub. Date : 2017 Sep
PMID : 28684382
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was revealed that androgen treatment with dihydrotestosterone (DHT) amplified progesterone synthesis in the presence of FSH and IGF-I, whereas it had no significant effect on estrogen synthesis by rat granulosa cells. | Dihydrotestosterone | insulin-like growth factor 1 | Rattus norvegicus |
| 2 | It was revealed that androgen treatment with dihydrotestosterone (DHT) amplified progesterone synthesis in the presence of FSH and IGF-I, whereas it had no significant effect on estrogen synthesis by rat granulosa cells. | Dihydrotestosterone | insulin-like growth factor 1 | Rattus norvegicus |
| 3 | In accordance with the effects of androgen on steroidogenesis, DHT enhanced the expression of progesterogenic factors and enzymes, including StAR, P450scc and 3betaHSD, and cellular cAMP synthesis induced by FSH and IGF-I. | Dihydrotestosterone | insulin-like growth factor 1 | Rattus norvegicus |
| 4 | Of note, treatment with DHT and IGF-I suppressed Smad1/5/8 phosphorylation and transcription of the BMP target gene Id-1, suggesting that androgen and IGF-I counteract BMP signaling that inhibits FSH-induced progesterone synthesis in rat granulosa cells. | Dihydrotestosterone | insulin-like growth factor 1 | Rattus norvegicus |