Pub. Date : 2017
PMID : 28659806
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. | erythrodiol | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 2 | We identified erythrodiol (Olean-12-ene-3beta,28-diol) as an ABCA1 stabilizer and revealed its positive influence on ChE in THP-1-derived human macrophages. | erythrodiol | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 3 | Among the nine tested compounds from olive oil, erythrodiol was the sole compound raising ABCA1 protein level (at 10 muM). | erythrodiol | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 4 | Besides, erythrodiol (10 muM) did not influence the mRNA level of ABCA1, ABCG1, and SR-B1, as determined by quantitative reverse transcription PCR, but significantly inhibited the degradation of ABCA1 as evident by an increased half-life of the protein in the presence of cycloheximide, an inhibitor of de novo protein synthesis. | erythrodiol | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 5 | Therefore, erythrodiol promotes ChE from THP-1-derived human macrophages by stabilizing the ABCA1 protein. | erythrodiol | ATP binding cassette subfamily A member 1 | Homo sapiens |