Title : Rapamycin inhibits CaCl2-induced thoracic aortic aneurysm formation in rats through mTOR-mediated suppression of proinflammatory mediators.

Pub. Date : 2017 Aug

PMID : 28656223






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In contrast, the CaCl2-induced TAA formation was inhibited by pre-administering rapamycin to CaCl2-treated rats, which demonstrated attenuated mTOR phosphorylation and downregulation of the proinflammatory mediators (i.e., TNF-alpha, IL-6, IL-1beta, matrix metallopeptidases 2 and 9) to the control level. Calcium Chloride interleukin 1 beta Rattus norvegicus
2 In contrast, the CaCl2-induced TAA formation was inhibited by pre-administering rapamycin to CaCl2-treated rats, which demonstrated attenuated mTOR phosphorylation and downregulation of the proinflammatory mediators (i.e., TNF-alpha, IL-6, IL-1beta, matrix metallopeptidases 2 and 9) to the control level. Calcium Chloride interleukin 1 beta Rattus norvegicus