Title : Excessive nNOS/NO/AMPK signaling activation mediated by the blockage of the CBS/H2S system contributes to oxygen‑glucose deprivation‑induced endoplasmic reticulum stress in PC12 cells.

Pub. Date : 2017 Aug

PMID : 28656194






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole nitric oxide synthase 1 Rattus norvegicus
2 3-Bromo-7-nitroindazole (3-Br-7-NI), a relatively selective nNOS inhibitor, abolished the OGD-induced inhibition of cell viability and the increased expression of ER stress-related proteins, including glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-12 in PC12 cells, indicating the contribution of excessive nNOS/NO signaling to OGD-induced ER stress. 3-bromo-7-nitroindazole nitric oxide synthase 1 Rattus norvegicus