Protein Name nitric oxide synthase 1
Organism Rattus norvegicus
Gene ID 24598
Gene Symbol


UniProt P29476 (NOS1_RAT), D3ZEW7 (D3ZEW7_RAT), F1LQL1 (F1LQL1_RAT)
Relationships Total Number of functionally related compound(s) : 760
Total Number of Articles : 1257

nitric oxide synthase 1

Gene Summary

Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including blood vessel diameter maintenance; regulation of cation transmembrane transport; and regulation of neuron death. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

  • nitric oxide synthase 1
  • N-NOS
  • NC-NOS
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