Title : Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis.

Pub. Date : 2017 Oct 18

PMID : 28653829






2 Functional Relationships(s)
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1 Our studies established that JC-171 dose dependently inhibited LPS/ATP-induced interleukin-1beta (IL-1beta) release from J774A.1 macrophages with an IC50 of 8.45 +- 1.56 muM. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 Our studies established that JC-171 dose dependently inhibited LPS/ATP-induced interleukin-1beta (IL-1beta) release from J774A.1 macrophages with an IC50 of 8.45 +- 1.56 muM. Adenosine Triphosphate interleukin 1 beta Mus musculus