Pub. Date : 2017 Aug 4
PMID : 28634231
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hyperactivity of the Arabidopsis cryptochrome (cry1) L407F mutant is caused by a structural alteration close to the cry1 ATP-binding site. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 2 | Hyperactivity of the Arabidopsis cryptochrome (cry1) L407F mutant is caused by a structural alteration close to the cry1 ATP-binding site. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 3 | The previously characterized L407F mutant allele of Arabidopsis cry1 is biologically hyperactive and seems to mimic the ATP-bound state of cry1, but the reason for this phenotypic change is unclear. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 4 | The previously characterized L407F mutant allele of Arabidopsis cry1 is biologically hyperactive and seems to mimic the ATP-bound state of cry1, but the reason for this phenotypic change is unclear. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 5 | Here, we show that cry1L407F can still bind ATP, has less pronounced photoreduction and formation of FADH than wild-type cry1, and has a dark reversion rate 1.7 times lower than that of the wild type. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 6 | Moreover, we show that ATP binds to cry1 in both the dark and the lit states. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 7 | Finally, we show that a recently discovered chemical inhibitor of cry1, 3-bromo-7-nitroindazole, competes for ATP binding and thereby diminishes FADH formation, which demonstrates that both processes are important for cry1 function. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |
| 8 | Finally, we show that a recently discovered chemical inhibitor of cry1, 3-bromo-7-nitroindazole, competes for ATP binding and thereby diminishes FADH formation, which demonstrates that both processes are important for cry1 function. | Adenosine Triphosphate | cryptochrome 1 | Arabidopsis thaliana |