Title : The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

Pub. Date : 2017 Aug 4

PMID : 28630043






1 Functional Relationships(s)
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1 Using enzyme kinetic assays under identical conditions, we observed clear differences between the three isoforms in intrinsic catalysis of GTP by Ras in the absence and presence of the Ras-binding domain (RBD) of the c-Raf kinase protein (Raf-RBD). Guanosine Triphosphate Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens