Title : Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes.

Pub. Date : 2017 Sep

PMID : 28627367






4 Functional Relationships(s)
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1 Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes. Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens
2 Rotenone, an inhibitor of mitochondrial complex I, can be used to trigger oxidative stress, stimulate the activation of Nrf2 pathway in neuronal and astrocytic cells and assess neurotoxicity. Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens
3 We have previously demonstrated that an acute treatment with rotenone can induce Nrf2 activation, which leads to astrocyte activation and dopaminergic (DA) neuronal cell death in a mixed neuronal/astrocytic cell model derived from human induced pluripotent stem cells (hiPSCs). Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens
4 Moreover, we observed that rotenone treatment induced a progressive activation of Nrf2 signaling together with a induction of astrocyte reactivity, a reduction of neurite length leading to neuronal cell death, in particular of DA neurons. Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens