Pub. Date : 2017
PMID : 28620394
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNgamma Secretion. | Vitamin D | interferon gamma | Homo sapiens |
| 2 | Paradoxically, vitamin D has repeatedly been ascribed an immune-suppressive function inhibiting Th1 differentiation and production of IFNgamma in T cells. | Vitamin D | interferon gamma | Homo sapiens |
| 3 | We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12. | Vitamin D | interferon gamma | Homo sapiens |
| 4 | We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12. | Vitamin D | interferon gamma | Homo sapiens |
| 5 | We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12. | Vitamin D | interferon gamma | Homo sapiens |
| 6 | In conclusion, we demonstrate that vitamin D counteracts M. tuberculosis-induced cathelicidin downregulation and allows Th1 differentiation and IFNgamma secretion. | Vitamin D | interferon gamma | Homo sapiens |