Title : Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats.

Pub. Date : 2017 Jun 15

PMID : 28619064






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1 CONCLUSION: The present study suggested that the anti-oxidant and anti-inflammatory effect of rutin may prevent CP-induced nephrotoxicity via decreasing the oxidative stress, inhibiting the interconnected ROS/JNK/TNF/P38 MAPK signaling pathways, and repairing the histopathological changes against cisplatin administration. Rutin mitogen-activated protein kinase 8 Rattus norvegicus