Title : Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization.

Pub. Date : 2017 Sep

PMID : 28616865






2 Functional Relationships(s)
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1 Isoacteoside blocked LPS-induced TLR4 dimerization, resulting in a reduction in the recruitment of MyD88 and TIR-domain-containing adapter-inducing interferon-beta (TRIF) and the phosphorylation of TGF-beta-activated kinase-1 (TAK1). isoacteoside myeloid differentiation primary response gene 88 Mus musculus
2 CONCLUSIONS AND IMPLICATIONS: Isoacteoside blocked TLR4 dimerization, which activates the MyD88-TAK1-NF-kappaB/MAPK signalling cascades and TRIF pathway. isoacteoside myeloid differentiation primary response gene 88 Mus musculus