Protein Name myeloid differentiation primary response gene 88
Organism Mus musculus
Gene ID 17874
Gene Symbol

Myd88

UniProt P22366 (MYD88_MOUSE), Q3U7M4 (Q3U7M4_MOUSE)
Relationships Total Number of functionally related compound(s) : 528
Total Number of Articles : 691
Description

myeloid differentiation primary response gene 88

Gene Summary

Enables Toll-like receptor binding activity and interleukin-1 receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in cerebral cortex; embryo; and telencephalon. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • myeloid differentiation primary response protein MyD88
  • myeloid differentiation primary response protein 88
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Properties