| Protein Name | myeloid differentiation primary response gene 88 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17874 |
| Gene Symbol | Myd88 |
| UniProt | P22366 (MYD88_MOUSE), Q3U7M4 (Q3U7M4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
528
Total Number of Articles : 691 |
Description |
myeloid differentiation primary response gene 88 |
| Gene Summary |
Enables ATP-dependent histone chaperone activity; signaling adaptor activity; and signaling receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within several processes, including establishment of endothelial intestinal barrier; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in several structures, including brain; intestine; and spleen. Used to study Alzheimer's disease; Coronavirus infectious disease; Sjogren's syndrome; and monoclonal gammopathy of uncertain significance. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Jun 2025] |
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