Pub. Date : 2017 Aug
PMID : 28608291
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron-induced generation of mitochondrial ROS depends on AMPK activity. | Iron | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS. | Iron | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS. | Iron | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | By contrast, AMPK inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ROS. | Iron | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and AMPK activity is important for the association of iron and mitochondria. | Iron | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |