Title : Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis.

Pub. Date : 2017 Sep

PMID : 28606823






1 Functional Relationships(s)
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1 ALA reduced BBB permeability and TNF-alpha levels in hippocampus in 24 h and IL-1beta levels and MPO activity in hippocampus and prefrontal cortex in 24 h. ALA reduced nitrite/nitrate concentration and lipid peroxidation in 24 h in all structures and protein carbonylation in 12 and 24 h in hippocampus and cortex. Thioctic Acid interleukin 1 beta Rattus norvegicus