Pub. Date : 2017 Sep 5
PMID : 28603047
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 2 | The upregulated expression of PDE5 in IPAH-PASMCs was significantly attenuated by a long-term treatment with tadalafil. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 3 | Taken together, these results indicate that tadalafil attenuates vascular remodeling by inhibiting cell proliferation, promoting apoptosis, and downregulating PDE5 in IPAH-PASMCs, thereby ameliorating IPAH. | Tadalafil | phosphodiesterase 5A | Homo sapiens |