Pub. Date : 1985 Mar
PMID : 2858160
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The recent description of the drug proglumide as a specific, competitive cholecystokinin (CCK)/gastrin receptor antagonist has permitted reevaluation of the role of CCK in this process. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 2 | The recent description of the drug proglumide as a specific, competitive cholecystokinin (CCK)/gastrin receptor antagonist has permitted reevaluation of the role of CCK in this process. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 3 | The recent description of the drug proglumide as a specific, competitive cholecystokinin (CCK)/gastrin receptor antagonist has permitted reevaluation of the role of CCK in this process. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 4 | In chronic pancreatic fistula dogs, dose-response studies were performed to determine the effect of proglumide on the pancreatic responses to octapeptide of CCK (CCK-OP), intravenous bethanechol, intraduodenal amino acids, and intraduodenal fat. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 5 | Pancreatic volume, protein, and bicarbonate outputs to all doses of CCK-OP were inhibited significantly (P less than 0.05) in a competitive manner, consistent with the proposed mode of action of proglumide. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 6 | If indeed proglumide is a specific CCK receptor antagonist, these results support the hypothesis that CCK is the major mediator of the intestinal phase of exocrine pancreatic secretion. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 7 | If indeed proglumide is a specific CCK receptor antagonist, these results support the hypothesis that CCK is the major mediator of the intestinal phase of exocrine pancreatic secretion. | Proglumide | cholecystokinin | Canis lupus familiaris |