Title : 1α,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression.

Pub. Date : 2017 Sep

PMID : 28578001






4 Functional Relationships(s)
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1 1alpha,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression. Calcitriol mitogen-activated protein kinase 14 Homo sapiens
2 By searching for a signal transduction pathway involved in 1,25(OH)2D3-induced expression of TRPV6, we found that a p38 mitogen-activated protein kinase (MAPK) inhibitor reduces the expression of TRPV6 but not CYP24A1 in 1,25(OH)2D3-treated SW480 cells. Calcitriol mitogen-activated protein kinase 14 Homo sapiens
3 By searching for a signal transduction pathway involved in 1,25(OH)2D3-induced expression of TRPV6, we found that a p38 mitogen-activated protein kinase (MAPK) inhibitor reduces the expression of TRPV6 but not CYP24A1 in 1,25(OH)2D3-treated SW480 cells. Calcitriol mitogen-activated protein kinase 14 Homo sapiens
4 Knockdown experiments showed that p38alpha is involved in 1,25(OH)2D3-induced expression of TRPV6 but not CYP24A1. Calcitriol mitogen-activated protein kinase 14 Homo sapiens