Pub. Date : 2017 Sep 15
PMID : 28576406
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages. | puerarin | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 2 | This study was designed to determine whether puerarin decreased lipid accumulation via up-regulation of ABCA1-mediated cholesterol efflux in THP-1 macrophage-derived foam cells. | puerarin | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 3 | Our results showed that puerarin significantly promoted the expression of ATP-binding cassette transporter A1 (ABCA1) mRNA and protein via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor gamma (PPARgamma)-liver X receptor-alpha (LXR-alpha) pathway and decreased cellular lipid accumulation in human THP-1 macrophage-derived foam cells. | puerarin | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 4 | Our results showed that puerarin significantly promoted the expression of ATP-binding cassette transporter A1 (ABCA1) mRNA and protein via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor gamma (PPARgamma)-liver X receptor-alpha (LXR-alpha) pathway and decreased cellular lipid accumulation in human THP-1 macrophage-derived foam cells. | puerarin | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 5 | Our study demonstrates that puerarin promotes ABCA1-mediated cholesterol efflux and decreases intracellular cholesterol levels through the pathway involving miR-7, STK11, and the AMPK-PPARgamma-LXR-alpha-ABCA1 cascade. | puerarin | ATP binding cassette subfamily A member 1 | Homo sapiens |
| 6 | Our study demonstrates that puerarin promotes ABCA1-mediated cholesterol efflux and decreases intracellular cholesterol levels through the pathway involving miR-7, STK11, and the AMPK-PPARgamma-LXR-alpha-ABCA1 cascade. | puerarin | ATP binding cassette subfamily A member 1 | Homo sapiens |