Title : Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines via Inhibition of NF-κB and STAT3 Pathways.

Pub. Date : 2017

PMID : 28566619






1 Functional Relationships(s)
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1 The inhibition was largely attributed to cell cycle arrest at the G1 phase through the reduction of cyclin D1, and cyclin E. Moreover, berberine could reduce the expression and activation of signal transducers and activator of transcription 3 (STAT3) and probably nuclear factor-kappaB (NF-kappaB) via suppression of extracellular signal-regulated kinase (ERK) 1/2 action. Berberine mitogen-activated protein kinase 3 Homo sapiens