Title : Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.

Pub. Date : 2017 Jul 13

PMID : 28561591






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Introduction of a m-fluorine in the benzyl moiety eventually led to the discovery of compound 21b, a potent inhibitor of Clk1 and -4 (IC50 = 7 and 2.3 nM, respectively), exhibiting an unprecedented selectivity over Dyrk1A. Fluorine CDC like kinase 1 Homo sapiens