Pub. Date : 2017 Sep 15
PMID : 28552776
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | PARP inhibition by arsenite enhances ultraviolet radiation (UVR)-induced DNA damage in keratinocytes, and the increase in DNA damage is reduced by zinc supplementation. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 6 | Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 7 | Zinc effectively restored DNA binding of PARP-1 and XPA to chromatin when zinc concentrations were equal to those of arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 8 | Taken together, our findings indicate that arsenite interferes with PARP-1 and XPA binding to chromatin, and that zinc supplementation fully restores DNA binding activity to both proteins in the cellular context. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 9 | Interestingly, rescue of arsenite-inhibited DNA damage repair by supplemental zinc was more sensitive for DNA damage repaired by the XPA-associated NER pathway than for the PARP-1-dependent BER pathway. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |