Pub. Date : 2017 Jul 13
PMID : 28552457
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Butylated hydroxyanisole alters rat 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase: Implications for influences of neurosteroidogenesis. | Butylated Hydroxyanisole | aldo-keto reductase family 1, member C14 | Rattus norvegicus |
| 2 | Butylated hydroxyanisole inhibited SRD5A1, AKR1C14, and RDH2 with IC50 values of 4.731+-0.079muM, 5.753+-0.073muM, and over 100muM, respectively. | Butylated Hydroxyanisole | aldo-keto reductase family 1, member C14 | Rattus norvegicus |
| 3 | Butylated hydroxyanisole is a competitive inhibitor for both SRD5A1 and AKR1C14. | Butylated Hydroxyanisole | aldo-keto reductase family 1, member C14 | Rattus norvegicus |
| 4 | Docking analysis shows that butylated hydroxyanisole binds to the dihydrotestosterone-binding site of AKR1C14. | Butylated Hydroxyanisole | aldo-keto reductase family 1, member C14 | Rattus norvegicus |
| 5 | In conclusion, butylated hydroxyanisole is a potent inhibitor of SRD5A1 and AKR1C14, thus reducing the formation of active neurosteroids. | Butylated Hydroxyanisole | aldo-keto reductase family 1, member C14 | Rattus norvegicus |