Pub. Date : 2017 Jul
PMID : 28534969
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | In this study, the CDK1 inhibitor, purvalanol A was applied to explore the relevance of Cdc2 signaling and taxol sensitivity through analyses, such as cellular proliferation and apoptosis assays, ELISA, western blot analysis and immunoprecipitation. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 5 | Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 6 | Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 7 | Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 8 | These findings suggest that Cdc2 is positively associatd with the development of taxol resistance. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 9 | The Cdc2 inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |