Pub. Date : 2017 Mar-Apr
PMID : 28534376
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VHL-TGFBI signaling is involved in the synergy between 5-aza-2"-deoxycytidine and paclitaxel against human renal cell carcinoma. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |
| 2 | PURPOSE: To analyse the role of von Hippel-Lindau (VHL) and transforming growth factor beta-induced (TGFBI) in synergistic mechanisms of 5-aza-2"-deoxycytidine (DAC) and paclitaxel (PTX) against renal cell carcinoma (RCC). | Paclitaxel | transforming growth factor beta induced | Homo sapiens |
| 3 | METHODS: To elucidate the role in the synergy between DAC and PTX against RCC cells, TGFBI expression was regulated using siRNA technology and an expression vector containing the full-length cDNA for TGFBI was also transfected into RCC cells. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |
| 4 | RESULTS: The results indicated that the expression of TGFBI was significantly decreased by DAC or PTX alone in vitro and in vivo. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |
| 5 | Moreover, the combination of DAC and PTX caused a synergistic decrease in the expression of TGFBI in RCC cells. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |
| 6 | CONCLUSIONS: Our study suggests that VHL-TGFBI signaling is involved in the synergy between DAC and PTX against RCC cells. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |