Title : Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts.

Pub. Date : 2017 Aug 15

PMID : 28532672






2 Functional Relationships(s)
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1 In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs). gallocatechol interleukin 6 Homo sapiens
2 EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression. gallocatechol interleukin 6 Homo sapiens