Pub. Date : 2017 May 21
PMID : 28531143
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines, Huh7 and Ha22T. | 4-hppp | MIR7-3 host gene | Homo sapiens |
| 2 | Our results showed that higher dosage of 4-HPPP downregulates the expression of alpha-tubulin and causes nuclear enlargement in both the Huh-7 and Ha22T cell lines. | 4-hppp | MIR7-3 host gene | Homo sapiens |
| 3 | The results of cellular proliferation assays, including trypan blue exclusion and colony formation, revealed that 4-HPPP inhibits the growth of Huh7 cells, but exerts less cytotoxicity in Ha22T cells. | 4-hppp | MIR7-3 host gene | Homo sapiens |
| 4 | Western blotting results showed 4-HPPP caused the increase of pro-apoptotic factors including cleaved caspase-3, Bid and Bax in HCC cells, especially in Huh-7. | 4-hppp | MIR7-3 host gene | Homo sapiens |
| 5 | Additionally, the level of gammaH2A histone family, member X (gammaH2AX), an endogenous DNA damage biomarker, was dramatically increased in Huh7 cells after 4-HPPP treatment, suggesting the involvement of DNA damage pathway in 4-HPPP-induced apoptosis. | 4-hppp | MIR7-3 host gene | Homo sapiens |
| 6 | Additionally, the level of gammaH2A histone family, member X (gammaH2AX), an endogenous DNA damage biomarker, was dramatically increased in Huh7 cells after 4-HPPP treatment, suggesting the involvement of DNA damage pathway in 4-HPPP-induced apoptosis. | 4-hppp | MIR7-3 host gene | Homo sapiens |