Title : From the Cover: ROS-Induced Store-Operated Ca2+ Entry Coupled to PARP-1 Hyperactivation Is Independent of PARG Activity in Necrotic Cell Death.

Pub. Date : 2017 Aug 1

PMID : 28525621






1 Functional Relationships(s)
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1 Under robust oxidative DNA damage, PARP-1 is hyperactivated, resulting in the depletion of NAD+ and ATP with accompanying elevations in intracellular calcium concentrations (iCa2+), and ultimately necrotic cell death. Calcium poly(ADP-ribose) polymerase 1 Homo sapiens